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Posts Tagged ‘Glutathione Levels’

Lou Gehrig’s Disease Linked to Low Glutathione Levels

August 1st, 2009

Although treatment for ALS, Lou Gehrig’s disease has still eluded those in the medical profession, scientists have discovered mechanisms that are underlying the disease process that are considered to be useful in the clinical management of ALS, giving new hope for significantly slowing the disease process and improving the quality of life for these patients.

 

The following article published in PubMed makes it very clear as to the possible benefits that increasing glutathione will have on slowing the progression of the disease. Although, this is not a “cure” it is certainly a step in the right direction in treating a disease that up until now has only one outcome.

A study of glutathione S-transferase pi expression in central nervous system of subjects with amyotrophic lateral sclerosis using RNA extraction from formalin-fixed, paraffin-embedded material.

Usarek E, Gajewska B, Ka?mierczak B, Ku?ma M, Dziewulska D, Bara?czyk-Ku?ma A.

Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland.

The expression of glutathione S-transferase pi (GST pi), an enzyme responsible for inactivation of a large variety of toxic compounds was studied in spinal cord, motor and sensory brain cortex obtained from patients who died in the course of amyotrophic lateral sclerosis (ALS). The studies were performed on formalin-fixed, paraffin-embedded (FFPE) and freshly frozen tissues. The method of RNA isolation from FFPE was modified. A significant decrease of GST pi-mRNA expression was found in cervical spinal cord and motor brain cortex of ALS subjects comparing to analogue control tissues (P<0.01), as well as in motor cortex of ALS subjects comparing to their sensory cortex (P<0.05). In spinal cords the decrease in GST pi-mRNA expression was accompanied by a decrease of GST pi protein level. Results indicated lowered GST pi expression on both mRNA and protein levels in the regions of nervous system affected by ALS. The non-properly inactivated by GST toxic electrophiles and organic peroxides may thus contribute to motor neurons damage.

 

What is Glutathione?

Glutathione’s role is to protect us against the main villains (toxins) that are at the root of aging and the multitude of diseases that are commonplace in society today. Glutathione in essence is the body’s Master Antioxidant! Yes, we have our own detoxification system built right in from birth.

Glutathione is rapidly consumed on a daily basis through normal metabolism, exercise and illnesses. We regenerate glutathione repeatedly but unfortunately more is lost than is manufactured by the body. We lose approximately 8 -12% of glutathione levels per decade from age 20 on. It is no wonder that the aging process seems to hit so many by their 40’s.

Without your glutathione levels at a optimum level, you have less than adequate defenses against may illnesses and diseases, including diabetes, heart disease, hypertension, lupus, Lou Gehrig’s disease and the list goes on.

How to Raise Your Glutathione Levels

Glutathione is made by the cells in our bodies from 3 amino acids: glycine, glutamate and cysteine.  Cysteine is the most important part of this equation and the most difficult to get. 

Research Scientist, Dr. Robert Keller, MD, MS, FACP, AAHIVS, the Director of Medicine and Research/KBK at the Institute of Advanced Medicine, has spent years on developing a way to help the body to produce glutathione to increase the quality of life for many of his patients. His research has lead to the revolutionary product that is a formulation of natural ingredients that is proven to increase the levels of glutathione in the body by 400%.

With Dr. Keller’s research and the many positive results that he has seen in the quality of life for his patients, he could see the potential for everyone taking this product to have a better quality of life, regardless of illness or age.

To find out more about Dr. Keller’s revolutionary product go to: MaxGXL Glutathione Accelerator

Amy McFarland Uncategorized

Medical Conditions Associated With Low Glutathione Levels

August 1st, 2009

Medical Conditions Associated With Low Glutathione Levels

Glutathione’s potential importance is being noted in a variety of diseases that are now being associated with decreased glutathione levels. For example, aging, Alzheimer’s and acne and in the most recent health scares, the Bird Flu and MRSA.

Consequences of Decreased Glutathione[i]

General:

Obesity, immune signaling, endothelial dysfunction, alcoholism, inflammation, heavy metal poisoning

Cardiovascular:

Angina and spastic angina, unstable angina, heart attacks, positive stress tests, reperfusion after cardiac bypass surgery

Pulmonary:

Emphysema (COPD), pulminary fibrosis (IPF), asthma, muscle wasting in COPD, chronic bronchitis, tobacco use

Neuro/Psych:

Migrane headaches, Alzheimer’s, Arkinson’s, multi infarct dementia, autism, ADHD (attention deficit hyperactivity disorder), bipolar disease, schizophrenia, Lou Gehrig’s disease, Huntington’s chorea, multiple sclerosis (MS), depression

Opthamology:

Cataracts, macular degeneration

Infectious Disease/Immunology:

Hepatitis a, b, and c; herpes simplex; herpes zoster/shingles; influenza and bird flu; HIV;  MRSA; common viral infections (upper respiratory, gastroenteritis); others

Rheumatology:

systemic lupus erythematosus (SLE);  rheumatoid arthritis (RA);  mulitiple sclerosis (MS);  systemic sclerosis (scleroderma) syndrome;  Behcet’s syndrome; ME/CFS; fibromyalgia; others

Dermatology:

Wrinkles, sagging; acne; psoriasis; atopic dermatitis;  exema; others

Oncology every cancer studied including:

brain; head and neck; thyroid; lung; esophagus; stomach; intestine; liver; pancreas; kidney; uterine; ovarian; prostrate; leukemia (acute and chronic); lymphoma; multiple myeloma; others

OB/GYN:

Infertility; spontaneous abortions; pre menstrual syndrome

Since there are few rigorous scientific studies demonstrating that increasing glutathione levels will improve the outcome of any disease or clinical condition, these statements have yet to meet the science demands of the cause and effect relationship.

It is just now coming into light that increasing glutathione levels has dramatically increased the quality of life for so many who are afflicted with these various diseases.

[i] “Glutathione-Your Best Defense Against Aging, Cellular Damage and Disease” by Dr. Robert H. Keller MD, MS, FACP, AAHIVS, Director of Medicine & Research/KBK Institute of Advanced Medicine

 

DISCLAIMER


Amy McFarland Autism and Glutathione, Decreased Glutathione Levels, Heart Disease and Glutathione, MaxGXL Glutathione Accelerator, Menopause and MaxGXL, Parkinson's and Glutathione, Uncategorized

Low Glutathione Levels Linked to Heart Disease

July 25th, 2009

Glutathione Deficiency in Cardiac Patients Is Related to the Functional Status and Structural Cardiac Abnormalities

Thibaud Damy,#1,2,3 Matthias Kirsch,#1,3 Lara Khouzami,2,3 Philippe Caramelle,2,3 Philippe Le Corvoisier,2,3,4,5 Françoise Roudot-Thoraval,3,6 Jean-Luc Dubois-Randé,1,2,3 Luc Hittinger,1,2,3 Catherine Pavoine,2,3 and Françoise Pecker1,2,3*
1AP-HP, Groupe hospitalier Henri-Mondor Albert-Chenevier, Fédération de Cardiologie, Département de Chirurgie Cardiaque, Créteil, France
2INSERM, U955, Créteil, France
3Université Paris12, Faculté de Médecine, UMR-S955, Créteil, France
4INSERM, Centre d’Investigation Clinique 006, Créteil, France
5Platform of biological resources, Groupe hospitalier Henri-Mondor Albert-Chenevier, Créteil, France
6AP-HP, Groupe hospitalier Henri-Mondor Albert-Chenevier, Département de Recherche Clinique- Santé Publique, Créteil, France
Alicia J. Kowaltowski, Editor
Instituto de Química, Universidade de São Paulo, Brazil
#Contributed equally.
* E-mail:francoise.pecker@inserm.fr
Conceived and designed the experiments: TD MK LK PLC JLDR LH CP FP. Performed the experiments: TD MK LK PC PLC FP. Analyzed the data: TD MK LK PC PLC FRT LH CP FP. Contributed reagents/materials/analysis tools: TD MK PLC JLDR FP. Wrote the paper: TD MK LK FRT LH CP FP.
Received December 2, 2008; Accepted February 2, 2009.

ABSTRACT

Background

The tripeptide glutathione (L-gamma-glutamyl-cysteinyl-glycine) is essential to cell survival, and deficiency in cardiac and systemic glutathione relates to heart failure progression and cardiac remodelling in animal models. Accordingly, we investigated cardiac and blood glutathione levels in patients of different functional classes and with different structural heart diseases.

Methods

Glutathione was measured using standard enzymatic recycling method in venous blood samples obtained from 91 individuals, including 15 healthy volunteers and 76 patients of New York Heart Association (NYHA) functional class I to IV, undergoing cardiac surgery for coronary artery disease, aortic stenosis or terminal cardiomyopathy. Glutathione was also quantified in right atrial appendages obtained at the time of surgery.

Results

In atrial tissue, glutathione was severely depleted (?58%) in NYHA class IV patients compared to NYHA class I patients (P=0.002). In patients with coronary artery disease, this depletion was related to the severity of left ventricular dysfunction (P=0.006). Compared to healthy controls, blood glutathione was decreased by 21% in NYHA class I patients with structural cardiac disease (P<0.01), and by 40% in symptomatic patients of NYHA class II to IV (P<0.0001). According to the functional NYHA class, significant depletion in blood glutathione occurred before detectable elevation in blood sTNFR1, a marker of symptomatic heart failure severity, as shown by the exponential relationship between these two parameters in the whole cohort of patients (r=0.88).

Conclusions

This study provides evidence that cardiac and systemic glutathione deficiency is related to the functional status and structural cardiac abnormalities of patients with cardiac diseases. These data also suggest that blood glutathione test may be an interesting new biomarker to detect asymptomatic patients with structural cardiac abnormalities.
To Read the complete Journal entry go to PubMed

Amy McFarland Consumer Lab, Decreased Glutathione Levels, Heart Disease and Glutathione, Max International, MaxGXL Glutathione Accelerator, Uncategorized

Parkinson’s and Glutathione

July 24th, 2009

The message is clear, low levels of glutathione are the cause of aging, disease, fatigue and a very long list of problems.  If you have ANY HISTORY of Heart disease, Stroke, Cancer, Diabetes, Dementia, Alzheimer’s or obesity you must protect yourself and the quality of life you have.  MaxGXL is that protection!

The only way to significantly raise GLUTATHIONE levels is with the patented MAX GXL GLUTATHIONE ACCELERATOR!

There is so much written on the subject, over 86,000 reports (PubMed), you can’t read it all.   Medical fact…glutathione is essential and will improve your health! FACT- the impact of MAXGXL is medically validated.

n  Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.

Parkinson disease (PD) typically affects the cortical regions during the later stages of disease, with neuronal loss, gliosis, and formation of diffuse cortical Lewy bodies in a significant portion of patients with dementia. To identify novel proteins involved in PD progression, we prepared synaptosomal fractions from the frontal cortices of pathologically verified PD patients at different stages along with age-matched controls. Protein expression profiles were compared using a robust quantitative proteomic technique. Approximately 100 proteins displayed significant differences in their relative abundances between PD patients at various stages and controls; three of these proteins were validated using independent techniques. One of the confirmed proteins, glutathione S-transferase Pi, was further investigated in cellular models of PD, demonstrating that its level was intimately associated with several critical cellular processes that are directly related to neurodegeneration in PD. These results have, for the first time, suggested that the levels of glutathione S-transferase Pi may play an important role in modulating the progression of PD.

Parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. The disease is also characterized by an increase in oxidative stress and a loss of glutathione in the midbrain region. A potential link between all these factors is the oxidation of dopamine to dopaminochrome (DAC). Using the murine mesencephalic cell line MN9D, we have shown that DAC [50 - 250muM] leads to cell death in a concentration-dependent manner, whereas oxidized L-dopa, dopachrome [50-250muM], is only toxic at the highest concentration used. Furthermore, chronic exposure of MN9D cells to low concentrations of DAC [50 - 100muM] is cytotoxic between 48 and 96h. DAC also increases superoxide production within MN9D cells as indicated by dihydroethidium fluorescence, that can be prevented by co-administration with the antioxidant, N-acetylcysteine [5mM]. Moreover, the cytotoxicity induced by DAC can also be prevented by administration of N-acetylcysteine [1 - 5mM]. Finally, depletion of reduced glutathione in MN9D cells by buthionine sulfoximine [50 - 100muM] administration significantly enhances the cytotoxic effect of low concentrations of DAC [50 - 100muM] and DAC [175muM] itself reduces the proportion of oxidized glutathione in total glutathione within 30min of administration in MN9D cells. Overall, we have shown that DAC causes MN9D cell death in an oxidatively-dependent manner that appears closely linked with a rapid loss of reduced glutathione. These findings have implications for understanding the pathogenesis of neurodegenerative pathways in Parkinson disease.

Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson’s disease explained via in silico studies.

 

DISCLAIMER

Amy McFarland MaxGXL Glutathione Accelerator, Parkinson's and Glutathione, Uncategorized

Energy Booster MaxGXL™ The Glutathione Accelerator

June 24th, 2009

Every cell in your body makes GlutathioneGlutathione is the master antioxidant of the body.  Without glutathione, we die. The replenishment of the glutathione levels by energy booster supplements increases the efficiency of the immune response, critical to health and longevity. Decreased glutathione, due to prolonged stress and hyperactivity of the immune system, compromises the health of the body’s cells.  As we produce energy, fires are created (free radicals), which causes fatigue, loss of energy, and stress.  Glutathione puts out all the fires, this is what makes it different from all the other antioxidants.  Benefits of antioxidants are well known, however glutathione is commonly being referred to as the master antioxidant.

Keeping glutathione in your body is difficult because as we age, we lose 10-15% of this master antioxidant every decade.  So by age fifty, we produce half the amount of glutathione.  No wonder why fatigue and loss of energy is common in so many lives.  Energy booster supplements such as MaxGXLTM work relentlessly to help your cell’s work more efficiently, so you can lead a healthier lifestyle.

Important Benefits of Glutathione

1.        Dramatically increases energy

2.        Boosts immune system

3.        Improves mental functions

4.        Enhances sense of well being

5.        Decreases stress

6.        Fights inflammation at cellular level

7.        Cellular detoxification

8.        Improve athletic performance

9.        Fights against oxidative cell damage from free radicals

Dr. Keller, a world renowned doctor patented a formula that provides the body with the ability to increase the production of glutathione.  MaxGXLTM is a natural antioxidant supplement that provides the proper nutrients needed to promote the body’s own ability to manufacture and absorb glutathione. It also aids in liver support, thus helping the liver to function as the main production site and storehouse for glutathione.

“This product [MaxGXLTM], in my opinion, represents the single most important breakthrough in health that we will witness in my life time I believe it will revolutionize, change, and transform the practice of medicine world-wide and make Dr Robert Keller more famous than Jonas Salk who created the polio vaccine.” — John Nelson MD, Immediate Past (159th) President American Medical Association

MaxGXLTM patented formula works more effectively than store bought glutathione, which is broken down by acid in the stomach long before it ever reaches the cells.  Knowing the benefits of antioxidants is important for a healthier lifestyle, and energy booster supplements such as these are also crucial to lowering the risk of certain diseases, such as cancer and heart disease.

DISCLAIMER

Amy McFarland Antioxidants and Free Radicals, Max International, MaxGXL Glutathione Accelerator, Uncategorized